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Literature summary extracted from

  • Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Job, Y.J.; Kim, S.
    Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases (2001), Bioorg. Med. Chem. Lett., 11, 965-968.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.5 isoleucyl isovanilloids e.g. the isovanillic hydroxamate and amide analogue Escherichia coli
6.1.1.5 isoleucyl vanilloids e.g. the vanillic hydroxamate with a phenolic hydoxyl at the para-position Escherichia coli
6.1.1.5 additional information the ribose of ATP/AMP can be substituted by its biosteres acyclic amide, hydroxamate, dihydroisooxazole, and dihydrooxazole, binding structure, overview Escherichia coli
6.1.1.10 isovanilloid analogues of L-methionyl adenylate overview, containing ribose biooisosteres Escherichia coli
6.1.1.10 vanilloid analogues of L-methionyl adenylate overview, containing ribose biooisosteres Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle Escherichia coli
-
 AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.10 ATP + L-methionine + tRNAMet Escherichia coli
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.5 Escherichia coli
-
-
-
6.1.1.10 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.10 ATP + L-methionine + tRNAMet
-
 Escherichia coli AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.5 IleRS
-
 Escherichia coli
6.1.1.5 IRS
-
 Escherichia coli
6.1.1.5 Isoleucine translase
-
 Escherichia coli
6.1.1.5 Isoleucine--tRNA ligase
-
 Escherichia coli
6.1.1.5 Isoleucine-transfer RNA ligase
-
 Escherichia coli
6.1.1.5 Isoleucine-tRNA synthetase
-
 Escherichia coli
6.1.1.5 Isoleucyl-transfer ribonucleate synthetase
-
 Escherichia coli
6.1.1.5 Isoleucyl-transfer RNA synthetase
-
 Escherichia coli
6.1.1.5 Isoleucyl-tRNA synthetase
-
 Escherichia coli
6.1.1.5 Mupirocin resistance protein
-
 Escherichia coli
6.1.1.5 Synthetase, isoleucyl-transfer ribonucleate
-
 Escherichia coli
6.1.1.10 Methionine translase
-
 Escherichia coli
6.1.1.10 Methionine--tRNA ligase
-
 Escherichia coli
6.1.1.10 Methionyl tRNA synthetase
-
 Escherichia coli
6.1.1.10 Methionyl-transfer ribonucleate synthetase
-
 Escherichia coli
6.1.1.10 Methionyl-transfer ribonucleic acid synthetase
-
 Escherichia coli
6.1.1.10 Methionyl-transfer RNA synthetase
-
 Escherichia coli
6.1.1.10 MetRS
-
 Escherichia coli
6.1.1.10 Synthetase, methionyl-transfer ribonucleate
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.5 ATP
-
 Escherichia coli
6.1.1.10 ATP
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.5 additional information
-
 additional information
-
 Escherichia coli
6.1.1.10 additional information
-
 additional information
-
 Escherichia coli