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Literature summary extracted from

  • Bernier, S.; Dubois, D.Y.; Therrien, M.; Lapointe, J.; Chenevert, R.
    Synthesis of glutaminyl adenylate analogues that are inhibitors of glutaminyl-tRNA synthetase (2000), Bioorg. Med. Chem. Lett., 10, 2441-2444.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.18 5'-O-[N-(L-glutaminyl)sulfamoyl] adenosine i.e. QSI, competitive to glutamine Escherichia coli
6.1.1.18 glutaminol adenylate competitive to glutamine Escherichia coli
6.1.1.18 glutaminol adenylate methyl phosphate ester competitive to glutamine Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.18 Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.18 ATP + L-glutamine + tRNAGln Escherichia coli
-
 AMP + diphosphate + L-glutaminyl-tRNAGln
-
 r

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.18 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.18 ATP + L-glutamine + tRNAGln
-
 Escherichia coli AMP + diphosphate + L-glutaminyl-tRNAGln
-
 r
6.1.1.18 ATP + L-glutamine + tRNAGln two-step reaction: 1. recognition of appropriate amino acid by the enzyme and formation of an enzyme-bound mixed anhydride, the aminoacyl-AMP, under release of diphosphate, 2. transfer of the activated amino acid to the CCA end of the cognate tRNA to form aminoacyl-tRNA and AMP, both steps are tRNA-dependent Escherichia coli AMP + diphosphate + L-glutaminyl-tRNAGln
-
 r

Synonyms

EC Number Synonyms Comment Organism
6.1.1.18 GlnRS
-
 Escherichia coli
6.1.1.18 Glutaminyl-tRNA synthetase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.18 ATP
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.18 0.00028
-
 glutaminol adenylate versus glutamine Escherichia coli
6.1.1.18 0.0013
-
 5'-O-[N-(L-glutaminyl)sulfamoyl] adenosine versus glutamine Escherichia coli
6.1.1.18 0.01
-
 glutaminol adenylate methyl phosphate ester versus glutamine Escherichia coli