BRENDA - Enzyme Database

Glutamyl adenylate analogs are inhibitors of glutamyl-tRNA synthetase

Desjardins, M.; Garneau, S.; Desgagnes, J.; Lacoste, L.; Yang, F.; Lapointe, J.; Chenevert, R.; Bioorg. Chem. 26, 1-13 (1998)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
6.1.1.17
glutamyl adenylate
-
Escherichia coli
6.1.1.17
glutamyl cytidylate
weak inhibition
Escherichia coli
6.1.1.17
glutamyl dihydrocytidylate
very weak inhibition
Escherichia coli
6.1.1.17
glutamyl N6-benzoyladenylate
-
Escherichia coli
6.1.1.17
glutamyl uridylate
very weak inhibition
Escherichia coli
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
6.1.1.17
Mg2+
required
Escherichia coli
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6.1.1.17
ATP + L-glutamate + tRNAGlu
Escherichia coli
-
AMP + diphosphate + L-glutamyl-tRNAGlu
-
Escherichia coli
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
6.1.1.17
Escherichia coli
-
pure enzyme
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6.1.1.17
ATP + L-glutamate + tRNAGlu
-
650511
Escherichia coli
AMP + diphosphate + L-glutamyl-tRNAGlu
-
650511
Escherichia coli
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
6.1.1.17
ATP
-
Escherichia coli
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
6.1.1.17
0.003
-
glutamyl adenylate
37°C
Escherichia coli
6.1.1.17
0.06
-
glutamyl N6-benzoyladenylate
37°C
Escherichia coli
6.1.1.17
0.63
-
glutamyl cytidylate
37°C
Escherichia coli
6.1.1.17
2.75
-
glutamyl uridylate
37°C
Escherichia coli
6.1.1.17
16.7
-
glutamyl dihydrocytidylate
37°C
Escherichia coli
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
6.1.1.17
ATP
-
Escherichia coli
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
6.1.1.17
glutamyl adenylate
-
Escherichia coli
6.1.1.17
glutamyl cytidylate
weak inhibition
Escherichia coli
6.1.1.17
glutamyl dihydrocytidylate
very weak inhibition
Escherichia coli
6.1.1.17
glutamyl N6-benzoyladenylate
-
Escherichia coli
6.1.1.17
glutamyl uridylate
very weak inhibition
Escherichia coli
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
6.1.1.17
0.003
-
glutamyl adenylate
37°C
Escherichia coli
6.1.1.17
0.06
-
glutamyl N6-benzoyladenylate
37°C
Escherichia coli
6.1.1.17
0.63
-
glutamyl cytidylate
37°C
Escherichia coli
6.1.1.17
2.75
-
glutamyl uridylate
37°C
Escherichia coli
6.1.1.17
16.7
-
glutamyl dihydrocytidylate
37°C
Escherichia coli
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
6.1.1.17
Mg2+
required
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6.1.1.17
ATP + L-glutamate + tRNAGlu
Escherichia coli
-
AMP + diphosphate + L-glutamyl-tRNAGlu
-
Escherichia coli
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6.1.1.17
ATP + L-glutamate + tRNAGlu
-
650511
Escherichia coli
AMP + diphosphate + L-glutamyl-tRNAGlu
-
650511
Escherichia coli
r