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Literature summary extracted from

  • Loak, K.; Li, D.N.; Manoury, B.; Billson, J.; Morton, F.; Hewitt, E.; Watts, C.
    Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl endopeptidase (2003), Biol. Chem., 384, 1239-1246.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.34 overexpression in CHO cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.34 2,2-dimethyl-propionic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester weak inhibition Homo sapiens
3.4.22.34 2,6-dimethyl-benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester enters cells and causes complete, irreversible inhibition of the enzyme, inhibition of autocatalytic processing in vivo Homo sapiens
3.4.22.34 benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester
-
 Homo sapiens
3.4.22.34 caspase 1 inhibitor V
-
 Homo sapiens
3.4.22.34 cystatin C
-
 Homo sapiens
3.4.22.34 additional information no inhibition by E-64 and leupeptin Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.34 endosome
-
 Homo sapiens 5768
-
3.4.22.34 lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.34 protein + H2O Homo sapiens enzyme is involved in antigen presentation within class II MHC positive cells and in pro-protein processing peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.34 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.34 proteolytic modification autolytic activation upon exposure to acidic pH Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.34 B-lymphocyte EBV-infected Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.34 benzyloxycarbonyl-Ala-Ala-Asn-4-methylcouamrin-7-amide + H2O
-
 Homo sapiens benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
 ?
3.4.22.34 myelin basic protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.34 protein + H2O
-
 Homo sapiens peptides
-
 ?
3.4.22.34 protein + H2O enzyme is involved in antigen presentation within class II MHC positive cells and in pro-protein processing Homo sapiens peptides
-
 ?
3.4.22.34 tetanus toxin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.34 AEP
-
 Homo sapiens
3.4.22.34 asparagine endopeptidase
-
 Homo sapiens
3.4.22.34 Asparaginyl endopeptidase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.34 25
-
 assay at Homo sapiens