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Literature summary extracted from

  • Ndjonka, D.; Zou, Y.; Bi, X.; Woster, P.; Walter, R.D.; Luersen, K.
    The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target (2003), Biol. Chem., 384, 1195-1201.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 1,15-diamino-4,12-diazapentadecane
-
 Onchocerca volvulus
4.1.1.50 1,5-Diaminopentane 57% of activation by putrescine Onchocerca volvulus
4.1.1.50 1,6-diaminohexane 58% of activation by putrescine Onchocerca volvulus
4.1.1.50 1,7-Diaminoheptane 45% of activation by putrescine Onchocerca volvulus
4.1.1.50 33-003
-
 Onchocerca volvulus
4.1.1.50 N1-acetylspermidine 60% of activation by putrescine Onchocerca volvulus
4.1.1.50 PMW-2000-11-13-5
-
 Onchocerca volvulus
4.1.1.50 putrescine
-
 Onchocerca volvulus
4.1.1.50 spermidine 82% of activation by putrescine Onchocerca volvulus
4.1.1.50 spermine 13% of activation by putrescine Onchocerca volvulus
4.1.1.50 YZ-33-046
-
 Onchocerca volvulus
4.1.1.50 YZ-33-050C
-
 Onchocerca volvulus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 BW-1 85% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance Homo sapiens
4.1.1.50 BW-1 99% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance Onchocerca volvulus
4.1.1.50 MDL 27695 44% inhibition at 2 mM, in presence of 2 mM putrescine Homo sapiens
4.1.1.50 MDL 27695 86% inhibition at 2 mM, in presence of 2 mM putrescine Onchocerca volvulus
4.1.1.50 PMW-2000-11-13-1 52% inhibition at 2 mM, in presence of 2 mM putrescine Homo sapiens
4.1.1.50 PMW-2000-11-13-1 97% inhibition at 2 mM, in presence of 2 mM putrescine Onchocerca volvulus
4.1.1.50 RHW-17-69-75 45% inhibition at 2 mM, in presence of 2 mM putrescine Homo sapiens
4.1.1.50 RHW-17-69-75 97% inhibition at 2 mM, in presence of 2 mM putrescine Onchocerca volvulus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Homo sapiens
-
-
-
4.1.1.50 Onchocerca volvulus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.50 1.3
-
 without activator Onchocerca volvulus
4.1.1.50 8
-
 plus 2 mM 1,15-diamino-4,12-diazapentadecane Onchocerca volvulus
4.1.1.50 8
-
 plus 2 mM 33-003 Onchocerca volvulus
4.1.1.50 19
-
 pus 2 mM YZ-33-050C Onchocerca volvulus
4.1.1.50 26
-
 plus 2 mM PMW-2000-11-13-5 Onchocerca volvulus
4.1.1.50 46
-
 plus 2 mM YZ-33-046 Onchocerca volvulus
4.1.1.50 79
-
 plus 2 mM putrescine Onchocerca volvulus
4.1.1.50 121
-
 plus 2 mM YZ-33-050C Homo sapiens
4.1.1.50 148
-
 plus 2 mM 33-003 Homo sapiens
4.1.1.50 152
-
 plus 2 mM PMW-2000-11-13-5 Homo sapiens
4.1.1.50 176
-
 plus 2 mM YZ-33-046 Homo sapiens
4.1.1.50 180
-
 plus 2 mM 1,15-diamono-4,12-diazapentadecane Homo sapiens
4.1.1.50 410
-
 plus 2 mM putrescine Homo sapiens