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Literature summary extracted from

  • Niestroj, A.J.; Feu฿ner, K.; Heiser, U.; Dando, P.M.; Barrett, A.J.; Gerhartz, B.; Demuth, H.U.
    Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones (2002), Biol. Chem., 383, 1205-1214.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.34 benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-benzyloxymethylketone moderate inhibition Sus scrofa
3.4.22.34 benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-bromoacetate
-
 Sus scrofa
3.4.22.34 benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-bromomethylketone strong specific and irreversible inhibition Sus scrofa
3.4.22.34 benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloroacetate
-
 Sus scrofa
3.4.22.34 benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloromethylketone strong specific and irreversible inhibition Sus scrofa
3.4.22.34 cystatin C endogenous inhibitor Sus scrofa
3.4.22.34 additional information construction and irreversible specific inhibition of the enzyme by several derivatives of Michael acceptor inhibitors based on the backbone benzyloxycarbonal-L-Ala-L-Ala-L-Asn, overview Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.34 lysosome
-
 Sus scrofa 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.34 protein + H2O Sus scrofa
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.34 Sus scrofa
-
 purified enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.34 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.34 protein + H2O
-
 Sus scrofa peptides
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.34 additional information
-
 additional information
-
 Sus scrofa