EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.B1 | Dextran sulfate | strongly accelerates autoactivation, strongest acceleration at 0.02 mg/ml of 5-kDa-dextran sulfate | Homo sapiens | |
3.4.21.B1 | heparin | strongly accelerates autoactivation, optimum concentration: 5-10 U/ml, presence of 7.5 U/ml reduces the half-life of the proenzyme from 12 min to 3.5 min | Homo sapiens | |
3.4.21.B1 | poly-L-lysine | strongly accelerates autoactivation | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.B1 | alpha2 antiplasmin | inhibits autoactivation at physiological concentrations | Homo sapiens | |
3.4.21.B1 | Aprotinin | potent serine protease inhibitor, inhibits autoactivation at physiological concentrations | Homo sapiens | |
3.4.21.B1 | C1 esterase inhibitor | inhibits autoactivation at physiological concentrations | Homo sapiens | |
3.4.21.B1 | PPACK | potent serine protease inhibitor, inhibits autoactivation at physiological concentrations | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.21.B1 | 70000 | - |
proenzyme, SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B1 | Protein + H2O | Homo sapiens | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.B1 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.21.B1 | proteolytic modification | autocatalytic activation | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.B1 | purification with 6M urea yields the single-chain zymogen, whereas native conditions yield the activated two-chain form | Homo sapiens |
EC Number | Renatured (Comment) | Organism |
---|---|---|
3.4.21.B1 | complete recovery of enzyme activity within 2 min of incubation at 1 M urea after denaturation in 6M urea | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.B1 | plasma | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B1 | coagulation factor FVII + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B1 | factor V + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B1 | factor VIII + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B1 | L-pyroglutamic acid-cyclo-hexylglycine-Arg-para-nitroanilide + H2O | P-3342, fluorogenic substrate | Homo sapiens | ? | - |
? | |
3.4.21.B1 | plasminogen activator precursor + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B1 | Protein + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.B1 | PHBSP | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.B1 | 6 | - |
- |
Homo sapiens |