Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Andriao-Escarso, S.H.; Soares, A.M.; Rodrigues, V.M.; Angulo, Y.; Diaz, C.; Lomonte, B.; Gutierrez, J.M.; Giglio, J.R.
    Myotoxic phospholipases A2 in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu (2000), Biochimie, 82, 755-763.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 2-nitrobenzenesulfonyl fluoride BthTX-I: myotoxic activity reduced to 75% and the cytotoxic activity reduced to 76% Bothrops spp.
3.1.1.4 4-bromophenacyl bromide BthTX-II: loses most of its catalytic, indirect haemolytic, anticoagulant, myotoxic and cytotoxic activity, BthTX-I: myotoxic activity reduced to 50% and the cytotoxic activity reduced to 13% Bothrops spp.
3.1.1.4 o-nitrophenylsulfonyl chloride BthTX-I: myotoxic activity reduced to 65% and the cytotoxic activity reduced to 58% Bothrops spp.
3.1.1.4 Rose bengal BthTX-I: myotoxic activity reduced to 20% and the cytotoxic activity reduced to 0.5% Bothrops spp.

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Bothrops spp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 venom
-
 Bothrops spp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.4 additional information
-
 BthTX-I has no enzymatic activity Bothrops spp.
3.1.1.4 37.08
-
 BthTX-II Bothrops spp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 additional information enzyme has indirect haemolytic, anticoagulant, myotoxic and cytotoxic activity Bothrops spp. ?
-
 ?