Any feedback?
Literature summary extracted from
- Reaction and substrate specificity of recombinant pig kidney DOPA decarboxylase under aerobic and anaerobic conditions (2003), Biochim. Biophys. Acta, 1647, 42-47.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.1.1.28 | medicine | development of dopamine treatment ainst Parkinson's disease, drug target for treatment of neurodgenerative diseases | Sus scrofa |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.28 | - |
Sus scrofa |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.28 | L-tryptophan | Sus scrofa | - |
tryptamine + CO2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.28 | Sus scrofa | - |
pig | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.28 | 5-hydroxy-L-tryptophan | - |
Sus scrofa | serotonin + CO2 | - |
? | |
| 4.1.1.28 | 5-hydroxytryptamine + O2 | side reaction, decarboxylation-dependent transamination | Sus scrofa | 5-hydroxyindolacetaldehyde + NH3 | - |
? | |
| 4.1.1.28 | alpha-methyl-dopamine + O2 | side reaction, decarboxylation-dependent transamination | Sus scrofa | 3,4-dihydroxyphenylacetone + NH3 | - |
? | |
| 4.1.1.28 | alpha-methyl-L-Dopa | - |
Sus scrofa | alpha-methyl-dopamine + CO2 | - |
? | |
| 4.1.1.28 | dopamine + O2 | - |
Sus scrofa | 3,4-dihydroxyphenylacetaldehyde + NH3 | - |
? | |
| 4.1.1.28 | L-Dopa | - |
Sus scrofa | dopamine + CO2 | - |
? | |
| 4.1.1.28 | L-tryptophan | - |
Sus scrofa | tryptamine + CO2 | - |
? | |
| 4.1.1.28 | additional information | exhibits half-transaminase activity toward D-aromatic amino acids and oxidative deaminase activity toward aromatic amines | Sus scrofa | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.28 | homodimer | - |
Sus scrofa |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.28 | DDC | - |
Sus scrofa |
| 4.1.1.28 | DOPA decarboxylase | - |
Sus scrofa |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.28 | pyridoxal 5'-phosphate | - |
Sus scrofa | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
