EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.1.8 | A328F | no substrate activation | Homo sapiens |
3.1.1.8 | A328Y | no substrate activation | Homo sapiens |
3.1.1.8 | E197D | moderately reduced substrate activation | Homo sapiens |
3.1.1.8 | E197G | strongly reduced substrate activation | Homo sapiens |
3.1.1.8 | E197Q | strongly reduced substrate activation | Homo sapiens |
3.1.1.8 | G328G | retained substrate activation | Homo sapiens |
3.1.1.8 | K339M | retained substrate activation | Homo sapiens |
3.1.1.8 | N83A | loss of substrate activation | Homo sapiens |
3.1.1.8 | N83Q | loss of substrate activation | Homo sapiens |
3.1.1.8 | W430A | retained substrate activation, strongly reduced affinity for tetramethylammonium, bimolecular rate constant for reaction with diisopropyl fluorophosphate is reduced 10000fold | Homo sapiens |
3.1.1.8 | W82A | apparent substrate activation at butytylthiocholine concentrations greater than 2 mM | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.8 | tetraethylammonium | - |
Homo sapiens | |
3.1.1.8 | Tetramethylammonium | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.8 | 0.003 | - |
succinylthiocholine | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.011 | - |
butyrylthiocholine | A328Y mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.017 | - |
butyrylthiocholine | A328F mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.019 | - |
succinylthiocholine | K339M mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.02 | - |
butyrylthiocholine | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.028 | - |
butyrylthiocholine | G328G mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.05 | - |
butyrylthiocholine | N83A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.06 | - |
butyrylthiocholine | N83Q and K339M mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.1 | - |
butyrylthiocholine | E197D and E197Q mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.12 | - |
2-Nitrophenyl butyrate | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.16 | - |
2-Nitrophenyl butyrate | K339M mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.2 | - |
butyrylthiocholine | E197G mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 0.4 | - |
butyrylthiocholine | W82A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 1.4 | - |
2-Nitrophenyl butyrate | W82A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 1.9 | - |
2-Nitrophenyl butyrate | W430A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 6 | - |
butyrylthiocholine | W430A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 11 | - |
succinylthiocholine | W430A mutant, pH 7, 25°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.8 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.8 | 2-nitrophenyl butyrate | - |
Homo sapiens | 2-nitrophenol + butyrate | - |
? | |
3.1.1.8 | butyrylthiocholine + H2O | - |
Homo sapiens | thiocholine + butyrate | - |
? | |
3.1.1.8 | succinylthiocholine + H2O | - |
Homo sapiens | thiocholine + succinate | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.8 | 2 | - |
butyrylthiocholine | W82A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 3 | - |
succinylthiocholine | K339M and W430A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 6 | - |
succinylthiocholine | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 67 | - |
butyrylthiocholine | E197D mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 83 | - |
butyrylthiocholine | W430A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 150 | - |
butyrylthiocholine | E197Q mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 250 | - |
butyrylthiocholine | K339M mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 250 | - |
2-Nitrophenyl butyrate | K339M mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 333 | - |
butyrylthiocholine | G328G mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 333 | - |
2-Nitrophenyl butyrate | W430A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 416 | - |
2-Nitrophenyl butyrate | W82A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 450 | - |
butyrylthiocholine | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 533 | - |
butyrylthiocholine | A328F mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 600 | - |
2-Nitrophenyl butyrate | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 617 | - |
butyrylthiocholine | N83A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 667 | - |
butyrylthiocholine | A328Y mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 767 | - |
butyrylthiocholine | N83Q mutant, pH 7, 25°C | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.8 | 2 | - |
tetraethylammonium | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 4 | - |
Tetramethylammonium | wild-type, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 11 | - |
Tetramethylammonium | K339M mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 70 | - |
Tetramethylammonium | E197G mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 400 | - |
tetraethylammonium | W82A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 500 | - |
Tetramethylammonium | W430A mutant, pH 7, 25°C | Homo sapiens | |
3.1.1.8 | 600 | - |
Tetramethylammonium | W82A mutant, pH 7, 25°C | Homo sapiens |