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Literature summary extracted from

  • Jehle, R.; Schlame, M.; Buttner, C.; Frey, B.; Sinha, P.; Rustow, B.
    Platelet-activating factor (PAF)-acetylhydrolase and PAF-like compounds in the lung: effects of hyperoxia (2001), Biochim. Biophys. Acta, 1532, 60-66.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 additional information enzyme activity of the bronchoalveolar lavage is reduced in hyperoxia, but not in plasma Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 extracellular secretion, association to membranes, plasma Rattus norvegicus
-
-
3.1.1.47 membrane cell surface Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Rattus norvegicus i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 alveolar cell type II
-
 Rattus norvegicus
-
3.1.1.47 bronchoalveolar lavage
-
 Rattus norvegicus
-
3.1.1.47 lung
-
 Rattus norvegicus
-
3.1.1.47 macrophage
-
 Rattus norvegicus
-
3.1.1.47 plasma
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.47 additional information
-
 hyperoxemic rats show reduced activity in bronchoalveolar lavage, but not in plasma Rattus norvegicus
3.1.1.47 0.47
-
 supernatant fraction Rattus norvegicus
3.1.1.47 0.55
-
 alveolar type II cells and 1000 x g fraction Rattus norvegicus
3.1.1.47 0.77
-
 macrophages Rattus norvegicus
3.1.1.47 0.85
-
 100000 x g fraction Rattus norvegicus
3.1.1.47 1.32
-
 60000 x g fraction Rattus norvegicus
3.1.1.47 3.7
-
 bronchoalveolar lavage Rattus norvegicus
3.1.1.47 27.1
-
 plasma Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Rattus norvegicus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma Rattus norvegicus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 (PAF)-acetylhydrolase
-
 Rattus norvegicus
3.1.1.47 PAF-AH
-
 Rattus norvegicus
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Rattus norvegicus