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Literature summary extracted from

  • Winstead, M.V.; Balsinde, J.; Dennis, E.A.
    Calcium-independent phospholipase A2: structure and function (2000), Biochim. Biophys. Acta, 1488, 28-39.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.4
-
 Mus musculus
3.1.1.4
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 bromoenol lactone 40% inhibition at 0.05 mM Homo sapiens
3.1.1.4 bromoenol lactone inhibits at 0.025 mM Mus musculus
3.1.1.4 methyl arachidonyl fluorophosphonate 80% inhibition at 0.001 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.4 cytosol
-
 Mus musculus 5829
-
3.1.1.4 cytosol
-
 Homo sapiens 5829
-
3.1.1.4 membrane
-
 Mus musculus 16020
-
3.1.1.4 membrane
-
 Homo sapiens 16020
-
3.1.1.4 membrane
-
 Rattus norvegicus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.4 61000
-
 cPLA2-gamma Mammalia
3.1.1.4 63000
-
 63000 Da and 77000 Da, iPLA2-gamma, SDS-PAGE Mammalia
3.1.1.4 77000
-
 63000 Da and 77000 Da, iPLA2-gamma, SDS-PAGE Mammalia
3.1.1.4 85000 88000
-
 Rattus norvegicus
3.1.1.4 85000 88000 aggregated form Mus musculus
3.1.1.4 85000 88000 aggregated form Homo sapiens
3.1.1.4 85000 88000 iPLA2 Mammalia
3.1.1.4 88000
-
 iPLA2-gamma, calculated from amino acid sequence Mammalia

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-
3.1.1.4 Mammalia
-
-
-
3.1.1.4 Mus musculus
-
-
-
3.1.1.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 muscle
-
 Rattus norvegicus
-
3.1.1.4 P-388D1 cell macrophage-like cell line Mus musculus
-
3.1.1.4 U937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O in mixed micelles with Triton X-100 Mus musculus 1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitic acid
-
 ?
3.1.1.4 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O in mixed micelles with Triton X-100 Homo sapiens 1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitic acid
-
 ?
3.1.1.4 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine + H2O in mixed micelles with Triton X-100 Mus musculus 1-palmitoyl-sn-glycero-3-phosphorylcholine + arachidonic acid
-
 ?
3.1.1.4 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine + H2O in mixed micelles with Triton X-100 Homo sapiens 1-palmitoyl-sn-glycero-3-phosphorylcholine + arachidonic acid
-
 ?
3.1.1.4 additional information enzyme exhibits lyspohospholipase activity, lysophospholipid transacylase acitivty and phospholipase A2 activity Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.4 oligomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 cPLA2-gamma
-
 Mammalia
3.1.1.4 Group VIA Ankyrin-1 syn: iPLA2-1, splice variant of iPLA2 Homo sapiens
3.1.1.4 Group VIA Ankyrin-2 syn: iPLA2-2, splice variant of iPLA2 Homo sapiens
3.1.1.4 Group VIA PLA2
-
 Mus musculus
3.1.1.4 Group VIA PLA2
-
 Homo sapiens
3.1.1.4 Group VIA-3 syn: iPLA2-2, splice variant of iPLA2 Homo sapiens
3.1.1.4 iPLA2
-
 Mammalia
3.1.1.4 iPLA2-gamma
-
 Mammalia