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Literature summary extracted from

  • Bessmertnaya, L.; Loiko, II; Goncharova, T.I.; Ivanov, N.V.; Rumsh, L.D.; Antonov, V.K.
    Specific cleavage of hybrid proteins by proteinase encoded by the KEX2 gene (1997), Biochemistry, 62, 850-857.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.61 DFP
-
 Saccharomyces cerevisiae
3.4.21.61 EDTA
-
 Saccharomyces cerevisiae
3.4.21.61 HgCl2
-
 Saccharomyces cerevisiae
3.4.21.61 human urine trypsin inhibitor most potent inhibitor Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.61 Golgi apparatus
-
 Saccharomyces cerevisiae 5794
-
3.4.21.61 membrane membrane-bound Saccharomyces cerevisiae 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.61 100000
-
 PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.61 additional information Saccharomyces cerevisiae transforming the precursors of biologically active agents into their functional forms, processing and conversion of prohormones ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.61 Saccharomyces cerevisiae
-
 yeast, strain X-2180, haploid cells
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.61
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.61 Ac-Leu-Lys-Arg-p-nitroanilide + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
3.4.21.61 additional information hydrolyzes peptides and proteins with basic amino acid pairs which are cleaved at the C-ends of their peptide bonds, cleaves specifically large recombinant proteins, for example a protein consisting of a gamma-interferon fragment linked to HIV1-proteinase via a Lys-Arg-containing peptide Saccharomyces cerevisiae ?
-
 ?
3.4.21.61 additional information transforming the precursors of biologically active agents into their functional forms, processing and conversion of prohormones Saccharomyces cerevisiae ?
-
 ?
3.4.21.61 Proinsulin + H2O cleaves human proinsulin at the peptide bond between Arg32 and Glu33 Saccharomyces cerevisiae Insulin + ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.61 7.5
-
-
 Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.61 6 9
-
 Saccharomyces cerevisiae