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Literature summary extracted from

  • Tuinstra, R.L.; Wang, C.Z.; Mitchell, G.A.; Miziorko, H.M.
    Evaluation of 3-hydroxy-3-methylglutaryl-coenzyme A lyase arginine-41 as a catalytic residue: Use of acetyldithio-coenzyme A to monitor product enolization (2004), Biochemistry, 43, 5287-5295.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.4
-
Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
4.1.3.4 D42A 4fold decrease in proton exchange Homo sapiens
4.1.3.4 H233A 10fold decrease in proton exchange Homo sapiens
4.1.3.4 R41M lower activity than R41Q mutant Homo sapiens
4.1.3.4 R41Q mutation leads to human HMG-CoA lyase deficiency Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.4 acetoacetate
-
Homo sapiens
4.1.3.4 acetyldithio-CoA
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.3.4 48
-
(S)-3-hydroxy-3-methylglutaryl-CoA wild-type Homo sapiens
4.1.3.4 62
-
(S)-3-hydroxy-3-methylglutaryl-CoA R41Q mutant Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.3.4 Mg2+ required, Km wild-type enzyme: 0.2mM, Km R41Q mutant: 0.088 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.4 additional information Homo sapiens last step in ketogenesis ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.4
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.4 (S)-3-Hydroxy-3-methylglutaryl-CoA
-
Homo sapiens Acetyl-CoA + acetoacetate
-
?
4.1.3.4 additional information last step in ketogenesis Homo sapiens ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.3.4 0.0004
-
(S)-3-hydroxy-3-methylglutaryl-CoA R41Q mutant Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.3.4 0.021
-
acetoacetate
-
Homo sapiens
4.1.3.4 0.17
-
acetyldithio-CoA
-
Homo sapiens