Literature summary extracted from

Bedsted, T.; Swanson, R.; Chuang, Y.J.; Bock, P.E.; Bjork, I.; Olson, S.T.
Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites (2003), Biochemistry, 42, 8143-8152.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.22	Factor VIIIa	-	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.22	antithrombin	almost no inhibition in the absence of heparin, strong acceleration of the inhibition rate in the presence of heparin and physiologic levels of Ca2+	Homo sapiens

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.4.21.22	Ca2+	4-8fold allosteric activation at 5 mM	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.22	factor X + H2O	Homo sapiens	-	factor Xa	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.22	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.22	D-cyclohexylglycyl-Gly-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	D-cyclohexylglycyl-Gly-Arg + 7-amino-4-methylcoumarin	-	?
3.4.21.22	D-cyclohexylglycyl-Gly-Arg-p-nitroanilide + H2O	-	Homo sapiens	D-cyclohexylglycyl-Gly-Arg + p-nitroaniline	-	?
3.4.21.22	factor X + H2O	-	Homo sapiens	factor Xa	-	?

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Release 2023.1 (January 2023)