EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.22.16 | additional information | mutant lacking the mini chain, loss of aminopeptidase activity, increase in endopeptidase activity | Homo sapiens |
3.4.22.16 | additional information | mutant lacking the mini chain, loss of aminopeptidase activity, increase in endopeptidase activity | Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.16 | bovine stefin B | - |
Homo sapiens | |
3.4.22.16 | chicken cystatin | - |
Homo sapiens | |
3.4.22.16 | human stefin A | - |
Homo sapiens | |
3.4.22.16 | human stefin B | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.22.16 | 0.025 | - |
benzoyl-L-Phe-L-Val-L-Arg-4-methylcoumaryl-7-amide | pH 6.5, 25°C, native enzyme | Sus scrofa | |
3.4.22.16 | 0.038 | - |
benzoyl-L-Phe-L-Val-L-Arg-4-methylcoumaryl-7-amide | pH 6.5, 25°C, mutant lacking the mini chain | Sus scrofa | |
3.4.22.16 | 0.082 | - |
benzoyl-L-Phe-L-Arg-7-amido-4-methylcoumarin | pH 6.5, 25°C, mutant lacking the mini chain | Sus scrofa | |
3.4.22.16 | 0.1 | - |
L-Arg-4-methylcoumaryl-7-amide | pH 6.5, 25°C, native enzyme | Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.16 | Homo sapiens | - |
recombinant protein lacking the mini chain | - |
3.4.22.16 | Sus scrofa | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.22.16 | proteolytic modification | mutant lacking the mini chain, autocatalytic processing at pH 5.0, 37°C, processing is accelerated in presence of 0.025 mg/ml of dextran, prolonged activation results in both cases in decrease of enzyme acivtiy | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.16 | benzoyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Sus scrofa | benzoyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
3.4.22.16 | benzoyl-L-Phe-L-Val-L-Arg-4-methylcoumaryl-7-amide + H2O | - |
Sus scrofa | benzoyl-L-Phe-L-Val-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
3.4.22.16 | L-Arg-4-methylcoumaryl-7-amide + H2O | - |
Sus scrofa | L-Arg + 7-amino-4-methylcoumarin | - |
? | |
3.4.22.16 | Z-L-Phe-L-Arg-4-methylcoumaryl-7-amide + H2O | - |
Sus scrofa | benzoyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.22.16 | 0.000000049 | - |
chicken cystatin | pH 6.5, 25°C, mutant lacking the mini chain | Homo sapiens | |
3.4.22.16 | 0.000000074 | - |
human stefin B | pH 6.5, 25°C, mutant lacking the mini chain | Homo sapiens | |
3.4.22.16 | 0.000000099 | - |
human stefin A | pH 6.5, 25°C, mutant lacking the mini chain | Homo sapiens | |
3.4.22.16 | 0.00000052 | - |
bovine stefin B | pH 6.5, 25°C, native enzyme | Homo sapiens |