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Literature summary extracted from
- Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va. Amino acid residues 323-331 of factor V represent an interactive site for activated factor X (2002), Biochemistry, 41, 12715-12728.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.6 | AP'4 | nonapeptide comprising amino acids 323-331 of factor Va, strong, inhibition of prothrombinase activity, noncompetitive with respect to prothrombin, inhibition mechanism | Homo sapiens |  |
| 3.4.21.6 | additional information | inhibition potential of overlapping peptides within the region of amino acids 307-348 of factor Va heavy chain | Homo sapiens | |
| 3.4.21.6 | N24R | peptide comprising amino acids 307-348 of the factor Va heavy chain, binds to membrane-bound factor Xa and inhibits its activity | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.6 | Homo sapiens | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.21.6 | selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.6 | prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.6 | More | factor Xa is part of the prothrombinase complex with Ca2+, phospholipids and factor Va | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.6 | factor Xa | - |
Homo sapiens |
| 3.4.21.6 | hXa | - |
Homo sapiens |
| 3.4.21.6 | More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.6 | 7.4 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.6 | Factor Va | binding site for factor Xa is located at amino acid residues 307-348 of the heavy chain, purified factor Va is not stable during rapid freezing and thawing | Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.6 | 0.0057 | - |
AP'4 | pH 7.4 | Homo sapiens | |
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Release 2023.1 (January 2023)
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