EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | S-adenosyl-L-methionine | 2fold activation, allosteric regulator | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.2.1.22 | - |
Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.2.1.22 | D444N | mutant is unresponsive to physiological S-adenosyl-L-methionine concentrations, but can be activated in the presence of supraphysiological concentrations | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | regulatory domain | exerts an inhibitory effect on the enzyme, deletion is correlated with a 1fold increase in catalytic activity | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.22 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.2.1.22 | fibroblast | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.2.1.22 | 2.65 | - |
wild-type enzyme in the presence of S-adenosyl-L-methionine | Homo sapiens |
4.2.1.22 | 3.95 | - |
D144N mutant in the presence of S-adenosyl-L-methionine | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.22 | L-Serine + homocysteine | - |
Homo sapiens | Cystathionine + H2O | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.2.1.22 | 48 | - |
stable up to | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | heme | - |
Homo sapiens | |
4.2.1.22 | pyridoxal 5'-phosphate | - |
Homo sapiens |