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Literature summary extracted from

  • Taoka, S.; Lepore, B.W.; Kabil, O.; Ojha, S.; Ringe, D.; Banerjee, R.
    Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme (2002), Biochemistry, 41, 10454-10461.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.22 additional information enzyme is more active under oxidizing conditions Homo sapiens
4.2.1.22 S-adenosyl-L-methionine activates 2fold Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.22
-
 Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.22 catalytic core, hanging drop vapor diffusion method Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.22 C272A 2fold lower heme content, 2fold lower specific activity, 2fold higher activity in the presence of S-adenosyl-L-methionine Homo sapiens
4.2.1.22 C274S 2fold lower heme content, 2fold lower specific activity, 2fold higher activity in the presence of S-adenosyl-L-methionine Homo sapiens
4.2.1.22 additional information deletion mutant CBSdeltaN43/deltaC143 lacking C-terminal and N-terminal amino acids Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Homo sapiens P35520
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.22
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-Serine + homocysteine beta-replacement reaction Homo sapiens Cystathionine + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 heme b-type heme Homo sapiens
4.2.1.22 pyridoxal 5'-phosphate
-
 Homo sapiens