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Literature summary extracted from

  • Chittur, S.V.; Klem, T.J.; Shafer, C.M.; Davisson, V.J.
    Mechanism for acivicin inactivation of triad glutamine amidotransferases (2001), Biochemistry, 40, 876-887.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.2 (5R)-acivicin
-
 Escherichia coli
6.3.5.2 (alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid trivial name acivicin Escherichia coli
6.3.5.2 6-diazo-5-oxo-L-norleucine
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.5.2 ATP + xanthosine 5'-phosphate + L-glutamine + H2O Escherichia coli
-
 AMP + diphosphate + GMP + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.2 Escherichia coli P04079
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.2 ATP + xanthosine 5'-phosphate + L-glutamine + H2O
-
 Escherichia coli AMP + diphosphate + GMP + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.5.2 GMPS
-
 Escherichia coli
6.3.5.2 guanosine monophosphate synthetase
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.5.2 0.00041
-
 (alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
-
 Escherichia coli
6.3.5.2 0.0052
-
 6-diazo-5-oxo-L-norleucine
-
 Escherichia coli
6.3.5.2 0.64
-
 (5R)-acivicin
-
 Escherichia coli