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Literature summary extracted from

  • Min, J.H.; Wilder, C.; Aoki, J.; Arai, H.; Inoue, K.; Paul, L.; Gelb, M.H.
    Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme (2001), Biochemistry, 40, 4539-4549.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.47 0.005
-
 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine below, plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.005
-
 1,2-dioctanoyl-sn-glycerol below, plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.005
-
 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine below, plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.005
-
 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine below, plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.005
-
 didecanoyl-phosphocholine below, plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.005
-
 1,2-dioctanoylethyleneglycol below, plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.006
-
 1-oleoyl-2-acetyl-sn-glycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.011
-
 1,2-didecanoyl-sn-glycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.047
-
 dioctanoyl-phosphocholine plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.055
-
 octyl acetate plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.086
-
 1-decanoyl-rac-glycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.136
-
 tributyryl-glycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 1.4
-
 1-octanoyl-rac-glycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 4.7
-
 dibutanoyl-phosphocholine plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 63
-
 butyl acetate plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 131
-
 triacetylglycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 143
-
 methyl butyrate plasma isozyme, pH 7.5, 22°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 membrane bound, plasma isozyme Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 additional information Homo sapiens plasma isozyme is bound to LDL and HDL particles ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-
3.1.1.47 Physarum sp.
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.47 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate stereochemistry Homo sapiens
a
3.1.1.47 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate stereochemistry Physarum sp.
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 plasma plasma isozyme pPAF-AH, and isozyme Ib Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1,2-didecanoyl-sn-glycerol + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.47 1,2-didecanoyl-sn-glycerol + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 1,2-dioctanoyl-sn-glycerol + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.47 1,2-dioctanoyl-sn-glycerol + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 1,2-dioctanoylethyleneglycol + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.47 1,2-dioctanoylethyleneglycol + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens 2-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine + H2O
-
 Physarum sp. 2-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 1-decanoyl-rac-glycerol + H2O
-
 Homo sapiens decanoate + glycerol
-
 ?
3.1.1.47 1-decanoyl-rac-glycerol + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 1-octanoyl-rac-glycerol + H2O
-
 Homo sapiens octanoate + glycerol
-
 ?
3.1.1.47 1-octanoyl-rac-glycerol + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 1-oleoyl-2-acetyl-sn-glycerol + H2O
-
 Homo sapiens 1-oleoyl-sn-glycerol + acetate
-
 ?
3.1.1.47 1-oleoyl-2-acetyl-sn-glycerol + H2O
-
 Physarum sp. 1-oleoyl-sn-glycerol + acetate
-
 ?
3.1.1.47 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
-
 Physarum sp. 1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens 1-octadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine + H2O
-
 Physarum sp. 1-octadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-3-octadecyl-sn-glycero-1-phosphocholine + H2O
-
 Homo sapiens 3-octadecyl-sn-glycero-1-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-3-octadecyl-sn-glycero-1-phosphocholine + H2O
-
 Physarum sp. 3-octadecyl-sn-glycero-1-phosphocholine + acetate
-
 ?
3.1.1.47 butyl acetate + H2O
-
 Homo sapiens butanol + acetate
-
 ?
3.1.1.47 butyl acetate + H2O
-
 Physarum sp. butanol + acetate
-
 ?
3.1.1.47 dibutanoyl-phosphocholine + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.47 dibutyryl-phosphocholine + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.47 dibutyryl-phosphocholine + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 didecanoyl-phosphocholine + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.47 didecanoyl-phosphocholine + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 dioctanoyl-phosphocholine + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.47 dioctanoyl-phosphocholine + H2O
-
 Physarum sp. ?
-
 ?
3.1.1.47 methyl butyrate + H2O
-
 Homo sapiens methanol + butyrate
-
 ?
3.1.1.47 methyl butyrate + H2O
-
 Physarum sp. methanol + butyrate
-
 ?
3.1.1.47 additional information substrate specificity, overview Physarum sp. ?
-
 ?
3.1.1.47 additional information substrate specificity of isozymes, overview Homo sapiens ?
-
 ?
3.1.1.47 additional information plasma isozyme is bound to LDL and HDL particles Homo sapiens ?
-
 ?
3.1.1.47 octyl acetate + H2O
-
 Homo sapiens octanol + acetate
-
 ?
3.1.1.47 octyl acetate + H2O
-
 Physarum sp. octanol + acetate
-
 ?
3.1.1.47 triacetylglycerol + H2O
-
 Homo sapiens diacetylglycerol + acetate
-
 ?
3.1.1.47 triacetylglycerol + H2O
-
 Physarum sp. diacetylglycerol + acetate
-
 ?
3.1.1.47 tributyrylglycerol + H2O
-
 Homo sapiens dibutyrylglycerol + butyrate
-
 ?
3.1.1.47 tributyrylglycerol + H2O
-
 Physarum sp. dibutyrylglycerol + butyrate
-
 ?
3.1.1.47 trioctanoylglycerol + H2O
-
 Homo sapiens dioctanoylglycerol + octanoate
-
 ?
3.1.1.47 trioctanoylglycerol + H2O
-
 Physarum sp. dioctanoylglycerol + octanoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 PAF-AH
-
 Homo sapiens
3.1.1.47 PAF-AH
-
 Physarum sp.
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Homo sapiens
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Physarum sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.47 22
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.1.47 0.25
-
 1-oleoyl-2-acetyl-sn-glycerol isozyme Ib, (alpha2)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.28
-
 octyl acetate plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.34
-
 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine isozyme Ib, (alpha1)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.68
-
 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine isozyme Ib, (alpha2)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 0.69
-
 octyl acetate isozyme Ib, (alpha1)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 1.1
-
 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine isozyme Ib, (alpha2)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 1.7
-
 triacetylglycerol isozyme Ib, (alpha1)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 1.9
-
 octyl acetate isozyme Ib, (alpha2)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 3
-
 1-oleoyl-2-acetyl-sn-glycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 3.2
-
 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine isozyme Ib, (alpha2)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 4.8
-
 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 6.08
-
 octyl acetate isozyme Ib, (alpha1)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 6.08
-
 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine isozyme Ib, (alpha2)2 subunit, pH 7.5, 22°C Homo sapiens
3.1.1.47 8.1
-
 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 16.5
-
 triacetylglycerol plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 24.6
-
 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine plasma isozyme, pH 7.5, 22°C Homo sapiens
3.1.1.47 37
-
 triacetylglycerol isozyme Ib, (alpha2)2 subunit, pH 7.5, 22°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.47 7.5
-
 assay at Homo sapiens