EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.13.22 | D-Ala-D-(2-difluorothio)glycine-OH | dipeptide-like mechanism-based inhibitor, cleavage of the substance results in formation of a highly reactive 4-thioquinone fluoromethide which covalently reacts with the enzyme resulting in irreversible inhibition, inhibition mechanism | Enterococcus sp. |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.13.22 | 0.11 | - |
D-Ala-D-Ala | pH 7.0, 37°C | Enterococcus sp. |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.13.22 | D-Ala-D-Ala + H2O | Enterococcus sp. | enzyme is required for vancomycin resistance in enterococci | D-Ala + D-Ala | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.13.22 | Enterococcus sp. | - |
purified recombinant enzyme overexpressed in Escherichia coli | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.13.22 | D-Ala-D-Ala + H2O | - |
Enterococcus sp. | D-Ala + D-Ala | - |
? | |
3.4.13.22 | D-Ala-D-Ala + H2O | enzyme is required for vancomycin resistance in enterococci | Enterococcus sp. | D-Ala + D-Ala | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.13.22 | D-Ala-D-Ala amino dipeptidase | - |
Enterococcus sp. |
3.4.13.22 | M15.011 | Merops-ID | Enterococcus sp. |
3.4.13.22 | VanX | - |
Enterococcus sp. |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.13.22 | 37 | - |
assay at | Enterococcus sp. |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.13.22 | 41 | - |
D-Ala-D-Ala | pH 7.0, 37°C | Enterococcus sp. |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.13.22 | 7 | - |
assay at | Enterococcus sp. |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.13.22 | 0.03 | - |
D-Ala-D-(2-difluorothio)glycine-OH | pH 7.0, 37°C | Enterococcus sp. |