EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.20 | 1-(indol-3-yl)glycerol 3-phosphate + L-serine | Salmonella enterica subsp. enterica serovar Typhimurium | alpha-subunit of the bienzyme complex, alpha-reaction | L-tryptophan + D-glyceraldehyde 3-phosphate | - |
? | |
4.2.1.20 | L-serine + indole | Salmonella enterica subsp. enterica serovar Typhimurium | beta-subunit of the bienzyme complex, beta-reaction | tryptophan + H2O | - |
? | |
4.2.1.20 | additional information | Salmonella enterica subsp. enterica serovar Typhimurium | last 2 steps of the tryptophan biosynthesis | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.20 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O | also catalyses the conversion of serine and indole into tryptophan and water, and of indoleglycerol phosphate into indole and glyceraldehyde phosphate (the latter reaction was listed formerly as EC 4.2.1.8), mechanism, ligand binding, unique ligand-mediated long-range cooperativity for substrate channeling, allosteric control, coordination of metabolic cycles | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.20 | 1-(indol-3-yl)glycerol 3-phosphate | alpha-subunit of the bienzyme complex, alpha-reaction | Salmonella enterica subsp. enterica serovar Typhimurium | D-glyceraldehyde 3-phosphate + indole | - |
? | |
4.2.1.20 | 1-(indol-3-yl)glycerol 3-phosphate + L-serine | alpha-subunit of the bienzyme complex, alpha-reaction | Salmonella enterica subsp. enterica serovar Typhimurium | L-tryptophan + D-glyceraldehyde 3-phosphate | - |
? | |
4.2.1.20 | L-serine + indole | beta-subunit of the bienzyme complex, beta-reaction | Salmonella enterica subsp. enterica serovar Typhimurium | L-tryptophan + H2O | - |
? | |
4.2.1.20 | L-serine + indole | beta-subunit of the bienzyme complex, beta-reaction | Salmonella enterica subsp. enterica serovar Typhimurium | tryptophan + H2O | - |
? | |
4.2.1.20 | additional information | the intermediate product indole is transferred from the alpha- to the beta-site through a 25 A long hydrophobic tunnel | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
4.2.1.20 | additional information | last 2 steps of the tryptophan biosynthesis | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.2.1.20 | More | crystal structure analysis, structure-function relationship, overview | Salmonella enterica subsp. enterica serovar Typhimurium |
4.2.1.20 | tetramer | alpha2beta2 complex | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.20 | TRPS | - |
Salmonella enterica subsp. enterica serovar Typhimurium |