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Literature summary extracted from

  • Thoden, J.B.; Wesenberg, G.; Raushel, F.M.; Holden, H.M.
    Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding (1999), Biochemistry, 38, 2347-2357.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.5.5 ornithine
-
Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.3.5.5 the structure of enzyme cocrystallized in the presence of the 5’-adenylylimidodiphosphate, is determined to 2.1 A by X-ray crystallographic analysis, the three active sites of enzyme communicate via domain movements, the first example of such a domain movement is described Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.5 UMP
-
Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.5.5 42000
-
alpha,beta, 1 * 42000 + 1 * 118000 Escherichia coli
6.3.5.5 118000
-
alpha,beta, 1 * 42000 + 1 * 118000 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3- Escherichia coli the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.5 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3-
-
Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
6.3.5.5 2 ATP + L-Gln + HCO3- the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
6.3.5.5 2 ATP + NH4+ + HCO3-
-
Escherichia coli 2 ADP + phosphate + carbamoyl phosphate
-
?

Subunits

EC Number Subunits Comment Organism
6.3.5.5 heterodimer alpha,beta, 1 * 42000 + 1 * 118000 Escherichia coli