EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.24.27 | TLN-inhibitor complex, 3 alpha-mercaptoacyldipeptides in the thermolysin active site crystallized, hexagonal crystals, space group P6(1)22, [(2S)-2-sulfanyl-3-phenylpropanoyl]Gly-(5-Ph)Pro, parameters a : b : 93.50 A, c : 131.30 A, [(2S)-2-sulfanyl-3-phenylpropanoyl]Phe-Tyr, a : b : 93.97 A, c : 131.79 A, [(2S,R)-2-sulfanylheptanoyl]Phe-Ala, a : b : 93.31 A, c : 131.83 A | Bacillus thermoproteolyticus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.27 | CGS-28,106 | - |
Bacillus thermoproteolyticus | |
3.4.24.27 | thiorphan | - |
Bacillus thermoproteolyticus | |
3.4.24.27 | [(2S)-2-sulfanyl-3-phenylpropanoyl]Gly-(5-Ph)Pro | - |
Bacillus thermoproteolyticus | |
3.4.24.27 | [(2S)-2-sulfanyl-3-phenylpropanoyl]Phe-Tyr | - |
Bacillus thermoproteolyticus | |
3.4.24.27 | [(2S,R)-2-sulfanylheptanoyl]Phe-Ala | - |
Bacillus thermoproteolyticus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.27 | 0.2 | - |
[3H]Tyr-Gly-Gly-Phe-Leu | pH 8.0, 37°C | Bacillus thermoproteolyticus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.24.27 | 34600 | - |
- |
Bacillus thermoproteolyticus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.27 | Bacillus thermoproteolyticus | P00800 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.27 | Tyr-Gly-Gly-Phe-Leu + H2O | - |
Bacillus thermoproteolyticus | ? | - |
? | |
3.4.24.27 | [3H]Tyr-Gly-Gly-Phe-Leu + H2O | - |
Bacillus thermoproteolyticus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.27 | EC 3.4.24.4 | formerly | Bacillus thermoproteolyticus |
3.4.24.27 | TLN | - |
Bacillus thermoproteolyticus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.27 | 0.000042 | - |
[(2S)-2-sulfanyl-3-phenylpropanoyl]Phe-Tyr | pH 8.0, 37°C | Bacillus thermoproteolyticus | |
3.4.24.27 | 0.000048 | - |
[(2S,R)-2-sulfanylheptanoyl]Phe-Ala | pH 8.0, 37°C | Bacillus thermoproteolyticus | |
3.4.24.27 | 0.0012 | - |
[(2S)-2-sulfanyl-3-phenylpropanoyl]Gly-(5-Ph)Pro | pH 8.0, 37°C | Bacillus thermoproteolyticus | |
3.4.24.27 | 0.0016 | - |
thiorphan | pH 8.0, 37°C | Bacillus thermoproteolyticus | |
3.4.24.27 | 0.0016 | - |
CGS-28,106 | pH 8.0, 37°C | Bacillus thermoproteolyticus |