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Literature summary extracted from
- Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps (1999), Biochemistry, 38, 11814-11826.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.17 | expression in Escherichia coli | Trypanosoma brucei |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.1.1.17 | K69A | ODC copurifies with amines, e.g. putrescine, similar affinity for pyridoxal 5'-phosphate as wild-type | Trypanosoma brucei |
| 4.1.1.17 | K69R | 0.02% of wild-type activity, binds diamines and amino acids with higher affinity than wild-type ODC | Trypanosoma brucei |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.17 | 0.18 | - |
L-ornithine | K69R mutant | Trypanosoma brucei |  |
| 4.1.1.17 | 0.4 | - |
L-ornithine | - |
Trypanosoma brucei | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.17 | L-ornithine | Trypanosoma brucei | - |
putrescine + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.17 | Trypanosoma brucei | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.17 | recombinant ODC | Trypanosoma brucei |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.17 | L-ornithine | - |
Trypanosoma brucei | putrescine + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.17 | ODC | - |
Trypanosoma brucei |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.17 | 15 | - |
L-ornithine | - |
Trypanosoma brucei | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.17 | pyridoxal 5'-phosphate | - |
Trypanosoma brucei | |
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Release 2023.1 (January 2023)
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