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Literature summary extracted from

  • Redinbo, M.R.; Bencharit, S.; Potter, P.M.
    Human carboxylesterase 1: from drug metabolism to drug discovery (2003), Biochem. Soc. Trans., 31, 620-624.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.1 medicine since the enzyme may be useful as a treatment for cocaine overdose, and may afford protection against chemical weapons like Sarin, Soman and VX gas, hCE1 could serve as both a drug and a drug target Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.1.1 crystal structure of hCE1 in complex with the cocaine analogue homatropine to 2.8 A resolution, and with the heroin analogue naloxone to 2.9 A resolution Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.1 cocaine + H2O Homo sapiens
-
 O-benzoylecgonine + methanol
-
 ?
3.1.1.1 additional information Homo sapiens the enzyme also catalyzes the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 cocaine + H2O
-
 Homo sapiens O-benzoylecgonine + methanol
-
 ?
3.1.1.1 additional information the enzyme also catalyzes the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 carboxylesterase 1
-
 Homo sapiens
3.1.1.1 HCE1
-
 Homo sapiens