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Literature summary extracted from

  • Eisaf, M.; Tselepis, A.D.
    Effect of hypolipidemic drugs on lipoprotein-associated platelet activating factor acetylhydrolase. Implication for atherosclerosis (2003), Biochem. Pharmacol., 66, 2069-2073.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.47 dyslipidemia induces an increase in total plasma enzyme activity and alters the enzyme distribution between proatherogenic apoB- and antiatherogenic apo L-containing lipoproteins by increasing the enzyme activity associated with apoB-containing lipoproteins, atorvastin and fenofibrate can restore the normal level by reduction of LDL amount Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 atorvastatin reduces LDL-associated enzyme activity by reduction of LDL amount, does not reduce enzyme secretion by macrophages Homo sapiens
3.1.1.47 fenofibrate decreases total plasma and LDL_associated enzyme activity but does not influence HDL-associated enzyme activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information Homo sapiens the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 macrophage secretion Homo sapiens
-
3.1.1.47 plasma plasma isozyme Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 lipoprotein-associated platelet-activating factor acetylhydrolase
-
 Homo sapiens
3.1.1.47 PAF-AH
-
 Homo sapiens
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Homo sapiens