Literature summary extracted from

Peebles, K.A.; Baker, R.K.; Kurz, E.U.; Schneider, B.J.; Kroll, D.J.
Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum) (2001), Biochem. Pharmacol., 62, 1059-1070.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.6.2.2	hypericin	inhibits DNA relaxation activity, potent antagonist of cleavage complex stabilization by chemotherapeutics etoposide and amsacrine	Homo sapiens

EC Number	Organism	UniProt	Comment	Textmining
5.6.2.2	Homo sapiens	-	-	-

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Release 2023.1 (January 2023)