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Literature summary extracted from

  • Brugger, R.; Reichel, C.; Garcia Alia, B.; Brune, K.; Yamamoto, T.; Tegeder, I.; Geissinger, G.
    Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiotics (2001), Biochem. Pharmacol., 61, 651-656.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + (R)-ibuprofen + CoA Rattus norvegicus (R)-ibuprofenoyl-CoA synthetase and long-chain acyl-CoA synthetase are identical enzymes that are involved in the metabolism of various xenobiotics AMP + diphosphate + (R)-ibuprofenoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.3
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 brain
-
 Rattus norvegicus
-
6.2.1.3 heart
-
 Rattus norvegicus
-
6.2.1.3 ileum
-
 Rattus norvegicus
-
6.2.1.3 kidney
-
 Rattus norvegicus
-
6.2.1.3 liver high expression Rattus norvegicus
-
6.2.1.3 lung
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2.1.3 0.017
-
 formation of (R)-ibuprofenoyl-CoA Rattus norvegicus
6.2.1.3 0.28
-
 formation of palmitoyl-CoA Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + (R)-ibuprofen + CoA 9% of the activity with palmitate Rattus norvegicus AMP + diphosphate + (R)-ibuprofenoyl-CoA
-
 ?
6.2.1.3 ATP + (R)-ibuprofen + CoA (R)-ibuprofenoyl-CoA synthetase and long-chain acyl-CoA synthetase are identical enzymes that are involved in the metabolism of various xenobiotics Rattus norvegicus AMP + diphosphate + (R)-ibuprofenoyl-CoA
-
 ?
6.2.1.3 ATP + arachidonate + CoA 85% of the activity with palmitate Rattus norvegicus AMP + diphosphate + arachidonoyl-CoA
-
 ?
6.2.1.3 ATP + hexanoate + CoA 4% of the activity with palmitate Rattus norvegicus AMP + diphosphate + hexanoyl-CoA
-
 ?
6.2.1.3 ATP + octanoate + CoA 20% of the activity with palmitate Rattus norvegicus AMP + diphosphate + octanoyl-CoA
-
 ?
6.2.1.3 ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 LACS
-
 Rattus norvegicus
6.2.1.3 R-ibuprofenoyl-CoA synthetase
-
 Rattus norvegicus