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Literature summary extracted from

  • Wierdl, M.; Morton, C.L.; Danks, M.K.; Potter, P.M.
    Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation (2000), Biochem. Pharmacol., 59, 773-781.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.8
-
 Equus caballus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.8 0.000106
-
 butyrylthiocholine pH 7.4, 37°C Equus caballus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.8 66000
-
 after removal of carbohydrate residues, SDS-PAGE Equus caballus
3.1.1.8 95000
-
 2 * 95000, SDS-PAGE Equus caballus
3.1.1.8 200000
-
 glycosylated protein, SDS-PAGE Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Equus caballus Q9N1N9
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.8 glycoprotein
-
 Equus caballus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.8
-
 Equus caballus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 liver
-
 Equus caballus
-
3.1.1.8 serum
-
 Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 7-ethyl-10-[4-(1-piperidine)-1-piperidino]carbonyloxycamtothecin + H2O anticancer drug irinotecan CPT-11 Equus caballus 7-ethyl-10-hydroxycamptothecin + ?
-
 ?
3.1.1.8 butyrylthiocholine + H2O
-
 Equus caballus thiocholine + butyrate
-
 ?
3.1.1.8 propionylthiocholine + H2O
-
 Equus caballus thiocholine + propionate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.8 dimer 2 * 95000, SDS-PAGE Equus caballus