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Literature summary extracted from

  • Patel, M.S.; Korotchkina, L.G.
    The biochemistry of the pyruvate dehydrogenase complex (2003), Biochem. Mol. Biol. Educ., 31, 5-15.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.43 spermine activates Mammalia

Application

EC Number Application Comment Organism
3.1.3.43 medicine overview, role of enzyme in diabetes and starvation Mammalia

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.43 Ca2+ activates, facilitates binding to substrate Mammalia
3.1.3.43 Mg2+ required, PDP2 is less sensitive to Mg2+ concentration than PDP1 Mammalia

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.43 Mammalia
-
 isoforms PDP1, PDP2
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate mechanism, overview Mammalia
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.43 adipose tissue high level of PDP2 Mammalia
-
3.1.3.43 liver high level of PDP2 Mammalia
-
3.1.3.43 skeletal muscle high level of PDP1 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.43 [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
 Mammalia [pyruvate dehydrogenase (lipoamide)] + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.43 heterodimer catalytic subunit beloging to the phosphatase 2C class plus regulatory subunit, a flavoprotein, overview, there are two isoforms of the catalytic subunit+++ Mammalia

Synonyms

EC Number Synonyms Comment Organism
3.1.3.43 PDP
-
 Mammalia
3.1.3.43 PDP1
-
 Mammalia
3.1.3.43 PDP2
-
 Mammalia