EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.5 | glycoprotein Ibalpha(1-282) peptide | binds to exosite II of the enzyme, inhibits activation of factor VIII to more than 70% | Homo sapiens | |
3.4.21.5 | glycoprotein Ibalpha(268-282) peptide | binds to exosite II of the enzyme, inhibits activation of factor VIII and cleavage of factor VIII(341-376) peptide to more than 70% | Homo sapiens | |
3.4.21.5 | HD22 | aptamer, mitogen | Homo sapiens | |
3.4.21.5 | sulfated glycoprotein Ibalpha(268-282) peptide | sulfated at all tyrosine residues, binds to exosite II of the enzyme, inhibits activation of factor VIII and cleavage of factor VIII(341-376) peptide to more than 70% | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.5 | additional information | - |
additional information | kinetics | Homo sapiens | |
3.4.21.5 | 0.112 | - |
factor VIII(341-376) peptide | pH 7.5, 25°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.5 | factor VIII + H2O | Homo sapiens | activation by cleavage of Arg372, Arg74, and Arg1689, plays a fundamental role in the amplification of the coagulation cascade | ? | - |
? | |
3.4.21.5 | factor X + H2O | Homo sapiens | proteolytic activation | factor Xa + propeptide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.5 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.5 | factor VIII + H2O | activation by cleavage of Arg372, Arg74, and Arg1689 involving exosite II, the heparin binding site | Homo sapiens | ? | - |
? | |
3.4.21.5 | factor VIII + H2O | activation by cleavage of Arg372, Arg74, and Arg1689, plays a fundamental role in the amplification of the coagulation cascade | Homo sapiens | ? | - |
? | |
3.4.21.5 | factor VIII(341-376) peptide + H2O | cleavage of Arg372 involving exosite II, the heparin binding site | Homo sapiens | ? | - |
? | |
3.4.21.5 | factor X + H2O | proteolytic activation | Homo sapiens | factor Xa + propeptide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.5 | alpha-thrombin | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.5 | 3 | 6 | factor VIII(341-376) peptide | pH 7.5, 25°C | Homo sapiens | |
3.4.21.5 | 3.24 | - |
factor VIII(341-376) peptide | pH 7.5, 25°C | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.5 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.5 | additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
3.4.21.5 | 0.000025 | - |
HD22 | pH 8.0, 25°C | Homo sapiens | |
3.4.21.5 | 0.0088 | - |
glycoprotein Ibalpha(1-282) peptide | pH 8.0, 25°C | Homo sapiens | |
3.4.21.5 | 0.054 | - |
glycoprotein Ibalpha(268-282) peptide | pH 8.0, 25°C | Homo sapiens |