EC Number | Application | Comment | Organism |
---|---|---|---|
4.1.1.45 | medicine | during the metabolism of tryptophan, ACMSD is able to influence directly the production of quinolinate, a potent endogenous excitotoxin, have roles in the pathogenesiof epilepsy, Huntington's disease, Alzheimer's disease and demetia resulting from AIDS, and picolinate which may influence the immune system in macrophages and apoptosis in human leukaemia cell lines | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.1.1.45 | cDNA cloning, ACMSD ORF is inserted into a mammalian expression vector and transfected into human hepatoma HepG2 cells | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.45 | 0.013 | - |
2-amino-3-carboxymuconate-6-semialdehyde | pH 6.0, 25°C, kidney enzyme | Rattus norvegicus | |
4.1.1.45 | 0.014 | - |
2-amino-3-carboxymuconate-6-semialdehyde | pH 6.0, 25°C, liver enzyme | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.1.1.45 | 38090 | - |
deduced from cDNA | Rattus norvegicus |
4.1.1.45 | 39000 | - |
SDS-PAGE | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Rattus norvegicus | important enzyme regulating tryptophan-niacin metabolism | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Rattus norvegicus Wistar | important enzyme regulating tryptophan-niacin metabolism | 2-aminomuconate-6-semialdehyde + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.45 | Rattus norvegicus | Q8R5M5 | Wistar strain | - |
4.1.1.45 | Rattus norvegicus | Q8R5M5 | rat, Wistar | - |
4.1.1.45 | Rattus norvegicus Wistar | Q8R5M5 | Wistar strain | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.1.45 | - |
Rattus norvegicus |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.1.1.45 | 8.07 | - |
in kidney | Rattus norvegicus |
4.1.1.45 | 8.82 | - |
in liver | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Rattus norvegicus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | important enzyme regulating tryptophan-niacin metabolism | Rattus norvegicus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Rattus norvegicus Wistar | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | important enzyme regulating tryptophan-niacin metabolism | Rattus norvegicus Wistar | 2-aminomuconate-6-semialdehyde + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.45 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | - |
Rattus norvegicus |
4.1.1.45 | ACMSD | - |
Rattus norvegicus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.1.1.45 | 40 | 60 | activity is decreased by 25% after 5 min at 40°C, but thereafter is stable for up to 30 min, activity is completely lost by incubation at 60°C for 30 min | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.45 | 5.5 | 6.5 | - |
Rattus norvegicus |