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Literature summary extracted from

  • Tanabe, A.; Egashira, Y.; Fukuoka, S.; Shibata, K.; Sanada, H.
    Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (2002), Biochem. J., 361, 567-575.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.1.1.45 medicine during the metabolism of tryptophan, ACMSD is able to influence directly the production of quinolinate, a potent endogenous excitotoxin, have roles in the pathogenesiof epilepsy, Huntington's disease, Alzheimer's disease and demetia resulting from AIDS, and picolinate which may influence the immune system in macrophages and apoptosis in human leukaemia cell lines Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.45 cDNA cloning, ACMSD ORF is inserted into a mammalian expression vector and transfected into human hepatoma HepG2 cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.45 0.013
-
 2-amino-3-carboxymuconate-6-semialdehyde pH 6.0, 25°C, kidney enzyme Rattus norvegicus
4.1.1.45 0.014
-
 2-amino-3-carboxymuconate-6-semialdehyde pH 6.0, 25°C, liver enzyme Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.45 38090
-
 deduced from cDNA Rattus norvegicus
4.1.1.45 39000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Rattus norvegicus important enzyme regulating tryptophan-niacin metabolism 2-aminomuconate-6-semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Rattus norvegicus Wistar important enzyme regulating tryptophan-niacin metabolism 2-aminomuconate-6-semialdehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.45 Rattus norvegicus Q8R5M5 Wistar strain
-
4.1.1.45 Rattus norvegicus Q8R5M5 rat, Wistar
-
4.1.1.45 Rattus norvegicus Wistar Q8R5M5 Wistar strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.45
-
 Rattus norvegicus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.45 8.07
-
 in kidney Rattus norvegicus
4.1.1.45 8.82
-
 in liver Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Rattus norvegicus 2-aminomuconate-6-semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate important enzyme regulating tryptophan-niacin metabolism Rattus norvegicus 2-aminomuconate-6-semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Rattus norvegicus Wistar 2-aminomuconate-6-semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate important enzyme regulating tryptophan-niacin metabolism Rattus norvegicus Wistar 2-aminomuconate-6-semialdehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.45 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
-
 Rattus norvegicus
4.1.1.45 ACMSD
-
 Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.45 40 60 activity is decreased by 25% after 5 min at 40°C, but thereafter is stable for up to 30 min, activity is completely lost by incubation at 60°C for 30 min Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.45 5.5 6.5
-
 Rattus norvegicus