EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | cardiolipin | anionic phospholipids required for activity, maximal activation at 1 mM, 21% of activation with phosphatidylserine | Plasmodium falciparum | |
3.1.4.12 | phosphatidic acid | anionic phospholipids required for activity, maximal activation at 1 mM, 33% of activation with phosphatidylserine | Plasmodium falciparum | |
3.1.4.12 | phosphatidylglycerol | anionic phospholipids required for activity, maximal activation at 1 mM, 79% of activation with phosphatidylserine | Plasmodium falciparum | |
3.1.4.12 | phosphatidylinositol | anionic phospholipids required for activity, maximal activation at 1 mM, 53% of activation with phosphatidylserine | Plasmodium falciparum | |
3.1.4.12 | phosphatidylserine | anionic phospholipids required for activity, maximal activation at 1 mM | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | scyphostatin | 0.005 mM, 50% inhibition, complete inhibition at 0.033 mM | Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.4.12 | 0.1 | - |
sphingomyelin | 37°C, pH 7.5 | Plasmodium falciparum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.12 | membrane | - |
Plasmodium falciparum | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | Mg2+ | required for activity, half-maximal activation at 1 mM | Plasmodium falciparum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | Plasmodium falciparum | - |
N-acylsphingosine + choline phosphate | - |
? | |
3.1.4.12 | sphingomyelin + H2O | Plasmodium falciparum Honduras 1 | - |
N-acylsphingosine + choline phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Plasmodium falciparum | - |
no. 1-CDC | - |
3.1.4.12 | Plasmodium falciparum Honduras 1 | - |
no. 1-CDC | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | - |
Plasmodium falciparum | N-acylsphingosine + choline phosphate | - |
? | |
3.1.4.12 | sphingomyelin + H2O | - |
Plasmodium falciparum Honduras 1 | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | neutral sphingomyelinase | - |
Plasmodium falciparum |
3.1.4.12 | SMase | - |
Plasmodium falciparum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 7 | 8 | - |
Plasmodium falciparum |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 5.5 | 9 | less than 5% of maximal activity at pH 5.5 and pH 9.0, respectively | Plasmodium falciparum |