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Literature summary extracted from

  • Hanada, K.; Mitamura, T.; Fukasawa, M.; Magistrado, P.A.; Horii, T.; Nishijima, M.
    Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum (2000), Biochem. J., 346, 671-677.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 cardiolipin anionic phospholipids required for activity, maximal activation at 1 mM, 21% of activation with phosphatidylserine Plasmodium falciparum
3.1.4.12 phosphatidic acid anionic phospholipids required for activity, maximal activation at 1 mM, 33% of activation with phosphatidylserine Plasmodium falciparum
3.1.4.12 phosphatidylglycerol anionic phospholipids required for activity, maximal activation at 1 mM, 79% of activation with phosphatidylserine Plasmodium falciparum
3.1.4.12 phosphatidylinositol anionic phospholipids required for activity, maximal activation at 1 mM, 53% of activation with phosphatidylserine Plasmodium falciparum
3.1.4.12 phosphatidylserine anionic phospholipids required for activity, maximal activation at 1 mM Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 scyphostatin 0.005 mM, 50% inhibition, complete inhibition at 0.033 mM Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.12 0.1
-
sphingomyelin 37°C, pH 7.5 Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 membrane
-
Plasmodium falciparum 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Mg2+ required for activity, half-maximal activation at 1 mM Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Plasmodium falciparum
-
N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O Plasmodium falciparum Honduras 1
-
N-acylsphingosine + choline phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Plasmodium falciparum
-
no. 1-CDC
-
3.1.4.12 Plasmodium falciparum Honduras 1
-
no. 1-CDC
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
Plasmodium falciparum N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O
-
Plasmodium falciparum Honduras 1 N-acylsphingosine + choline phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase
-
Plasmodium falciparum
3.1.4.12 SMase
-
Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 7 8
-
Plasmodium falciparum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.12 5.5 9 less than 5% of maximal activity at pH 5.5 and pH 9.0, respectively Plasmodium falciparum