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Literature summary extracted from

  • Voilley, N.; Roduit, R.; Vicaretti, R.; Bonny, C.; Waeber, G.; Dyck, J.R.B.; Lopaschuk, G.D.; Prentki, M.
    Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase (1999), Biochem. J., 340, 213-217.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.9 from pancreatic beta cell line INS-1, expression in human kidney 293 cells, sequencing Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.9 mitochondrial matrix INS-1 MCD, expression most likely in, contains an N-terminal mitochondrial targeting sequence Rattus norvegicus 5759
-
4.1.1.9 peroxisome INS-1 MCD, expression most likely inside, the C-terminal part of enzyme ends with a peroxisomal targeting motif Rattus norvegicus 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.9 54700
-
 x * 54700, recombinant INS-1 MCD, enzyme might multimerize in vivo, calculated from the amino acid sequence Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.9 Malonyl-CoA Rattus norvegicus role in detoxification by preventing malonyl-CoA accumulation catalysed by propionyl -CoA carboxylase, in pancreatic beta cells MCD might act as an off signal for insulin release Acetyl-CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.9 Rattus norvegicus
-
 Wistar rat
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.1.1.9 additional information INS-1 MCD, sequence shows multiple possible sites of phosphorylation by casein kinase II and protein kinase C, no acylation sites Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.9 Malonyl-CoA
-
 Rattus norvegicus Acetyl-CoA + CO2
-
 ?
4.1.1.9 Malonyl-CoA role in detoxification by preventing malonyl-CoA accumulation catalysed by propionyl -CoA carboxylase, in pancreatic beta cells MCD might act as an off signal for insulin release Rattus norvegicus Acetyl-CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.9 ? x * 54700, recombinant INS-1 MCD, enzyme might multimerize in vivo, calculated from the amino acid sequence Rattus norvegicus