Literature summary extracted from

Mizushina, Y.; Ikuta, A.; Endoh, K.; Oshige, M.; Kasai, N.; Kamiya, K.; Satake, T.; Takazawa, H.; Morita, H.; Tomiyasu, H.; Yoshida, H.; Sugawara, F.; Sakaguchi, K.
Inhibition of DNA polymerases and DNA topoisomerase II by triterpenes produced by plant callus (2003), Biochem. Biophys. Res. Commun., 305, 365-373.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.6.2.2	3alpha-corosolic acid	IC50: 0.083 mM; IC50: 0.089 mM	Homo sapiens
5.6.2.2	3beta-corosolic acid	IC50: 0.049 mM	Homo sapiens
5.6.2.2	betulinic acid	IC50: 0.08 mM	Homo sapiens
5.6.2.2	corosolic acid	IC50: 0.043 mM	Homo sapiens
5.6.2.2	maslinic acid	IC50: 0.092 mM	Homo sapiens
5.6.2.2	oleanolic acid	IC50: 0.081 mM	Homo sapiens
5.6.2.2	ursolic acid	IC50: 0.036 mM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.2.2	Homo sapiens	-	topoisomerase IIalpha	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
5.6.2.2	0.0108	-	ursolic acid	-	Homo sapiens
5.6.2.2	0.0494	-	3beta-corosolic acid	-	Homo sapiens

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
5.6.2.2	0.036	-	IC50: 0.036 mM	Homo sapiens	ursolic acid
5.6.2.2	0.043	-	IC50: 0.043 mM	Homo sapiens	corosolic acid
5.6.2.2	0.049	-	IC50: 0.049 mM	Homo sapiens	3beta-corosolic acid
5.6.2.2	0.08	-	IC50: 0.08 mM	Homo sapiens	betulinic acid
5.6.2.2	0.081	-	IC50: 0.081 mM	Homo sapiens	oleanolic acid
5.6.2.2	0.083	-	IC50: 0.083 mM	Homo sapiens	3alpha-corosolic acid
5.6.2.2	0.089	-	IC50: 0.089 mM	Homo sapiens	3alpha-corosolic acid
5.6.2.2	0.092	-	IC50: 0.092 mM	Homo sapiens	maslinic acid

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)