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Literature summary extracted from

  • Guo, R.; Rowe, P.S.; Liu, S.; Simpson, L.G.; Xiao, Z.S.; Darryl Quarles, L.D.
    Inhibition of MEPE cleavage by Phex (2002), Biochem. Biophys. Res. Commun., 297, 38-45.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B15 expression of wild-type and mutant enzyme in Spodoptera frugiperda Sf9 cells via baculovirus infection, recombinant enzyme is located in the membranes of the Sf9 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B15 additional information construction of an inactive C-terminal deletion mutant of the enzyme Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B15 EDTA inhibits proteolyic activity but not the protease inhibiting activity of the enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B15 protein + H2O Mus musculus inactivating mutations cause X-linked hypophosphatemia, i.e. XLH, which results in the local accumulation of an unknown autocrine/paracrine factor in bone that inhibits mineralization of extracellular matrix peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B15 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B15 additional information the recombinant enzyme, but not the C-terminal deletion mutant, inhibited the cleavage of recombinant human matrix phosphoglycoprotein MEPE by endogenous cathepsin-like enzyme activity in SF9 insect cells, MEPE is no substrate for PHEX Mus musculus ?
-
 ?
3.4.24.B15 protein + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B15 protein + H2O inactivating mutations cause X-linked hypophosphatemia, i.e. XLH, which results in the local accumulation of an unknown autocrine/paracrine factor in bone that inhibits mineralization of extracellular matrix Mus musculus peptides
-
 ?
3.4.24.B15 ZAAL-4-nitroanilide + H2O recombinant wild-type enzyme, not the recombinant mutant Mus musculus Z-Ala-Ala-Leu + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B15 M13.091 Merops-ID Mus musculus
3.4.24.B15 PHEX
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B15 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.B15 6.5
-
 assay at Mus musculus