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Literature summary extracted from

  • Rodriguez-Manzaneque, J.C.; Westling, J.; Thai, S.N.; Luque, A.; Knauper, V.; Murphy, G.; Sandy, J.D.; Iruela-Arispe, M.L.
    ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors (2002), Biochem. Biophys. Res. Commun., 293, 501-508.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B11 E385A point mutation in the zinc binding domain results in an inactive mutant enzyme form Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B11 1,10-phenanthroline complete inhibition Homo sapiens
3.4.24.B11 doxycycline partial inhibition Homo sapiens
3.4.24.B11 EDTA complete inhibition Homo sapiens
3.4.24.B11 heparin
-
 Homo sapiens
3.4.24.B11 matrix metalloprotease inhibitor BB94
-
 Homo sapiens
3.4.24.B11 matrix metalloprotease inhibitor I partial inhibition Homo sapiens
3.4.24.B11 matrix metalloprotease inhibitor TIMP2 slight inhibition Homo sapiens
3.4.24.B11 matrix metalloprotease inhibitor TIMP3 slight inhibition Homo sapiens
3.4.24.B11 additional information no inhibition by minocycline, and matrix metalloprotease inhibitors TIMP1 and TIMP4 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B11 Zn2+ zinc-binding domain is essential for catalytic activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B11 aggrecan + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.B11 proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B11 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B11 proteolytic modification cleavage of prodomain by furin at furin-cleavage site RKKR Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B11 aggrecan + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B11 additional information no activity with pro-collagen type I and III, collagen types I, II, IV, V, VIII and XVIII, fibronectin, laminin, vibronectin, and thrombospondin 1 Homo sapiens ?
-
 ?
3.4.24.B11 peptide fragments of aggrecan + H2O peptide sequences contain the cleavage site of aggrecan at E373-A374 Homo sapiens ?
-
 ?
3.4.24.B11 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B11 versican + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B11 a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Homo sapiens
3.4.24.B11 ADAMTS1
-
 Homo sapiens
3.4.24.B11 M12.222 Merops-ID Homo sapiens