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Literature summary extracted from
- The catalytic properties of human carbonic anhydrase IX (2001), Biochem. Biophys. Res. Commun., 288, 666-669.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.1.1 | cDNA expressed in Escherichia coli BL21(DE3)pLysS | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | acetazolamide | - |
Homo sapiens |  |
| 4.2.1.1 | Cyanate | - |
Homo sapiens | |
| 4.2.1.1 | ethoxzolamide | - |
Homo sapiens | |
| 4.2.1.1 | methazolamide | - |
Homo sapiens | |
| 4.2.1.1 | sulfonamide | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.2.1.1 | membrane | integral membrane protein | Homo sapiens | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | Zn2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | glycoprotein | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | alpha-class carbonic anhydrase | - |
Homo sapiens |
| 4.2.1.1 | CA II | - |
Homo sapiens |
| 4.2.1.1 | CA IX | - |
Homo sapiens |
| 4.2.1.1 | human carbonic anhydrase IX | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.1 | 7.2 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.1 | 5 | 9 | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 0.000003 | - |
acetazolamide | pH 7.6, 4°C | Homo sapiens | |
| 4.2.1.1 | 0.000009 | - |
methazolamide | pH 7.6, 4°C | Homo sapiens | |
| 4.2.1.1 | 0.046 | - |
Cyanate | pH 7.6, 4°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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