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Literature summary extracted from

  • Tepper, A.D.; Ruurs, P.; Borst, J.; van Blitterswijk, W.J.
    Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis (2001), Biochem. Biophys. Res. Commun., 280, 634-639.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 expression in COS7 and Jurkat T cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 E49A no activity Homo sapiens
3.1.4.12 H272A no activity Homo sapiens
3.1.4.12 N180A no activity Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.12 45000
-
 x * 45000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens O60906
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.12 ? x * 45000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase
-
 Homo sapiens
3.1.4.12 nSMase1
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.12 additional information
-
 neutral pH required for activity Homo sapiens