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Literature summary extracted from

  • Zhou, M.; Graham, R.; Russell, G.; Croucher, P.I.
    MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin (2001), Biochem. Biophys. Res. Commun., 280, 574-580.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B9 expression of GST-enzyme disintegrin domain fusion protein Escherichia coli strain BL21 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B9 additional information construction of a GST-enzyme disintegrin domain fusion protein Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B9 additional information interaction of the enzyme with integrins is inhibited by antibodies against the alphaVbeta5-domain of integrin Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B9 additional information interaction of the enzyme with integrins is dependent on Ca2+ or Mn2+ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B9 additional information Homo sapiens the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+ ?
-
?
3.4.24.B9 proteins + H2O Homo sapiens
-
peptides
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B9 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B9 additional information the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+ Homo sapiens ?
-
?
3.4.24.B9 proteins + H2O
-
Homo sapiens peptides
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B9 M12.209 Merops-ID Homo sapiens
3.4.24.B9 MDC-9
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B9 37
-
cell adhesion assay at Homo sapiens