EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.35 | Zn2+ | 77% inhibition of proteolytic activity at 2.5 mM, completely reversible by L-cystein, phenanthroline, and L-histidine, Zn2+ interferes with the fibronectin binding of the amoeba | Entamoeba histolytica |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.35 | protein + H2O | Entamoeba histolytica | - |
peptides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.35 | Entamoeba histolytica | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.35 | trophozoite | - |
Entamoeba histolytica | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.35 | azocasein + H2O | - |
Entamoeba histolytica | fragments of azocasein | - |
? | |
3.4.22.35 | Gelatin + H2O | - |
Entamoeba histolytica | ? | - |
? | |
3.4.22.35 | additional information | enzyme permits adhesion of trophozoites to cells via fibronectin binding, which can be inhibited by Zn2+ | Entamoeba histolytica | ? | - |
? | |
3.4.22.35 | protein + H2O | - |
Entamoeba histolytica | peptides | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.35 | Entamoeba histolytica cysteine-proteinase | - |
Entamoeba histolytica |