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Literature summary extracted from

  • Behal, R.H.; Lin, M.; Back, S.; Oliver, D.J.
    Role of acetyl-coenzyme A synthetase in leaves of Arabidopsis thaliana (2002), Arch. Biochem. Biophys., 402, 259-267.
    View publication on PubMed

General Stability

EC Number General Stability Organism
6.2.1.1 KCl stabilizes Pisum sativum

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.1 acetyl-CoA competitive to CoASH Pisum sativum
6.2.1.1 ADP competitive to ATP Pisum sativum
6.2.1.1 AMP competitive to ATP Pisum sativum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.1 0.026
-
 acetyl-CoA pH 8.0 Pisum sativum
6.2.1.1 0.16
-
 acetate pH 8.0 Pisum sativum
6.2.1.1 0.52
-
 ATP pH 8.0 Pisum sativum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.1 Mg2+ MgATP2- is the actual substrate Pisum sativum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.1 ATP + acetate + CoA Arabidopsis thaliana no relationship between the enzyme level and the capacity of the plants to incorporate CO2 into labeled fatty acids. Very limited role of the enzyme in the biosynthesis of lipids AMP + diphosphate + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.1 Arabidopsis thaliana
-
-
-
6.2.1.1 Pisum sativum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.1 leaf from plants with altered ACS levels Arabidopsis thaliana
-
6.2.1.1 shoot
-
 Pisum sativum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.1 ATP + acetate + CoA
-
 Pisum sativum AMP + diphosphate + acetyl-CoA
-
 ?
6.2.1.1 ATP + acetate + CoA
-
 Arabidopsis thaliana AMP + diphosphate + acetyl-CoA
-
 ?
6.2.1.1 ATP + acetate + CoA no relationship between the enzyme level and the capacity of the plants to incorporate CO2 into labeled fatty acids. Very limited role of the enzyme in the biosynthesis of lipids Arabidopsis thaliana AMP + diphosphate + acetyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.1 ACS
-
 Pisum sativum
6.2.1.1 ACS
-
 Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.1 8.3 10.2 in 25 mM KCl buffer Pisum sativum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.2.1.1 6.8 10.1 about 50% of maximal activity at pH 6.8 and pH 10.1 Pisum sativum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.2.1.1 2.7
-
 acetyl-CoA pH 8.0 Pisum sativum
6.2.1.1 12
-
 ADP pH 8.0 Pisum sativum
6.2.1.1 15
-
 AMP pH 8.0 Pisum sativum