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Literature summary extracted from

  • Kosarikov, D.N.; Young, P.; Uversky, V.N.; Gerber, N.C.
    Human soluble guanylate cyclase: functional expression, purification and structural characterization (2001), Arch. Biochem. Biophys., 388, 185-197.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 NO sGC activity increases 8fold upon binding of NO Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 expression in Sf9 insect cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.2 recombinant sGC, ion-exchange, hydroxyapatite, gel filtration Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.6.1.2 0.94
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
 Homo sapiens
4.6.1.2 soluble guanylate cyclase
-
 Homo sapiens