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Literature summary extracted from

  • Heikkilae, P.; Teronen, O.; Moilanen, M.; Konttinen, Y.T.; Hanemaaijer, R.; Laitinen, M.; Maisi, P.; van der Pluijm, G.; Bartlett, J.D.; Salo, T.; Sorsa, T.
    Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines (2002), Anticancer Drugs, 13, 245-254.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B4 alendronate inhibits the in vitro invasion and random cell migration, 99% inhibition at 0.4 mM and physiological Ca2+-concentration, 67% inhibition at 0.4 mM and high Ca2+-concentration Homo sapiens
3.4.24.B4 clodronate 77% inhibition at 0.4 mM and physiological Ca2+-concentration, 35.7% inhibition at 0.4 mM and high Ca2+-concentration Homo sapiens
3.4.24.17 alendronate
-
 Homo sapiens
3.4.24.17 bisphosphonate
-
 Homo sapiens
3.4.24.17 clodronate
-
 Homo sapiens
3.4.24.17 pamidronate
-
 Homo sapiens
3.4.24.17 zoledronate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B4 protein + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B4 Homo sapiens
-
-
-
3.4.24.17 Homo sapiens
-
 human
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B4 proteolytic modification autoactivation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B4 C81-61 cell melanoma cell line Homo sapiens
-
3.4.24.B4 HT-1080 cell fibrosaocoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B4 beta-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B4 protein + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.17 beta-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.17 Fibronectin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B4 M10.013 Merops-ID Homo sapiens
3.4.24.B4 matrix metalloproteinase-13
-
 Homo sapiens
3.4.24.B4 MMP-13
-
 Homo sapiens
3.4.24.17 MMP-3
-
 Homo sapiens
3.4.24.17 stromelysin-1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B4 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.B4 7.8
-
 assay at Homo sapiens