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Literature summary extracted from
- Radiochemical malonyl-CoA decarboxylase assay: activity and subcellular distribution in heart and skeletal muscle (2002), Anal. Biochem., 306, 283-289.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.1.1.9 | mitochondrion | 50% of MCD activity in heart and 65% in skeletal muscle is localized to mitochondria, while 50% and 35% is extramitochondrial | Rattus norvegicus | 5739 | - |
| 4.1.1.9 | additional information | subcellular distribution | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.9 | Malonyl-CoA | Rattus norvegicus | main route for the disposal of malonyl-CoA, the key metabolite in the regulation of mitochondrial fatty acid oxidation | Acetyl-CoA + CO2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.9 | Rattus norvegicus | - |
male 6-months-old Fisher 344 rats | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.9 | Malonyl-CoA | - |
Rattus norvegicus | Acetyl-CoA + CO2 | - |
? | |
| 4.1.1.9 | Malonyl-CoA | main route for the disposal of malonyl-CoA, the key metabolite in the regulation of mitochondrial fatty acid oxidation | Rattus norvegicus | Acetyl-CoA + CO2 | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | 8 | 9.5 | - |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | 7.7 | - |
pH 7.7: 90% of the maximum activity measured at pH 8-9.5, assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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