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Literature summary extracted from

  • Fukuoka, S.; Tanabe, A.; Egashira, Y.; Sanada, H.; Shin, M.; Shibata, K.
    Identification of cDNAs encoding alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSDase) (1999), Adv. Exp. Med. Biol., 467, 615-618.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.45 cDNA cloning Mus musculus
4.1.1.45 cDNA cloning Homo sapiens
4.1.1.45 cDNA cloning Rattus norvegicus
4.1.1.45 cDNA cloning Sus scrofa
4.1.1.45 cDNA cloning Caenorhabditis elegans

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.45 Monoiodoacetic acid
-
 Sus scrofa
4.1.1.45 p-chloromercuribenzoic acid
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.45 0.0161
-
 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.45 41000
-
-
 Rattus norvegicus
4.1.1.45 41000
-
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Mus musculus key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Homo sapiens key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Rattus norvegicus key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Sus scrofa key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Caenorhabditis elegans key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway 2-aminomuconate semialdehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.45 Caenorhabditis elegans
-
 nematode
-
4.1.1.45 Homo sapiens
-
 human
-
4.1.1.45 Mus musculus
-
 mouse
-
4.1.1.45 Rattus norvegicus
-
 rat
-
4.1.1.45 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.45
-
 Rattus norvegicus
4.1.1.45
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Mus musculus 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Homo sapiens 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Rattus norvegicus 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Sus scrofa 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Caenorhabditis elegans 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway Mus musculus 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway Homo sapiens 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway Rattus norvegicus 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway Sus scrofa 2-aminomuconate semialdehyde + CO2
-
 ?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate key enzyme in the regulation of the tryptophan-nicotinamide adenine dinucleotide pathway Caenorhabditis elegans 2-aminomuconate semialdehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.45 ACMSDase
-
 Mus musculus
4.1.1.45 ACMSDase
-
 Homo sapiens
4.1.1.45 ACMSDase
-
 Rattus norvegicus
4.1.1.45 ACMSDase
-
 Sus scrofa
4.1.1.45 ACMSDase
-
 Caenorhabditis elegans
4.1.1.45 alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Mus musculus
4.1.1.45 alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Homo sapiens
4.1.1.45 alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Rattus norvegicus
4.1.1.45 alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Sus scrofa
4.1.1.45 alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Caenorhabditis elegans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.45 7.5
-
-
 Sus scrofa