Literature summary extracted from

Janosik, M.; Meier, M.; Kery, V.; Oliveriusova, J.; Burkhard, P.; Kraus, J.P.
Crystallization and preliminary x-ray diffraction analysis of the active core of human recombinant cystathionine beta-synthase: an enzyme involved in vascular disease (2001), Acta Crystallogr. Sect. D, D57, 289-291.

Application

EC Number	Application	Comment	Organism
4.2.1.22	medicine	inherited deficiency leads to homocystinuria, an autosomal recessivlely inherited disease of sulfur metabolism	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
4.2.1.22	truncated form fused with glutathione S-transferase	Homo sapiens

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
4.2.1.22	with heme and pyridoxal 5'-phosphate, hanging drop vapor diffusion method	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.1.22	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
4.2.1.22	-	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.2.1.22	L-Serine + homocysteine	-	Homo sapiens	Cystathionine + H2O	-	?

Subunits

EC Number	Subunits	Comment	Organism
4.2.1.22	dimer	truncated form of the enzyme	Homo sapiens
4.2.1.22	oligomer	full length subunits for tetramers and higher oligomers	Homo sapiens
4.2.1.22	tetramer	full length subunits for tetramers and higher oligomers	Homo sapiens

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Release 2023.1 (January 2023)