Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fishman, R.; Ankilova, V.; Moor, N.; Safro, M.
    Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese (2001), Acta Crystallogr. Sect. D, 57, 1534-1544.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.20 native enzyme complexed with phenylalanyl-adenylate in presence of manganese, X-ray diffraction structure determination at 2.6 A resolution and analysis Thermus thermophilus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.20 Mn2+ not bound to the active site, located at the interface of alpha and beta subunits Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe Thermus thermophilus
-
 AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.20 Thermus thermophilus
-
 class II enzyme
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.20 ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe reaction mechanism Thermus thermophilus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe
-
 Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?
6.1.1.20 ATP + L-phenylalanine + tRNAPhe two-step reaction, the first step, formation of phenylalanyl-adenylate intermediate, proceeds also within crystals, where the intermediate is bound to the active site involving neighbouring residues Phe258 and Phe260 Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?
6.1.1.20 additional information the enzyme probably interacts with DNA Thermus thermophilus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.20 CML33
-
 Thermus thermophilus
6.1.1.20 FRS
-
 Thermus thermophilus
6.1.1.20 HSPC173
-
 Thermus thermophilus
6.1.1.20 L-Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine translase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine--tRNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl transfer ribonucleic acid synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer ribonucleate synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer RNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer RNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-tRNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 PheRS
-
 Thermus thermophilus
6.1.1.20 Synthetase, phenylalanyl-transfer ribonucleate
-
 Thermus thermophilus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.20 ATP
-
 Thermus thermophilus